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Bacterial Membranes : Structural and Molecular Biology
by Fronzes, Remi

9781908230270Han Remaut (Editor); Remi Fronzes (Editor)Bacterial Membranes: Structural and Molecular BiologyMembranes are pivotal components of life, acting as formidable insulators that demarcate a living cell; generate energy in the form of ion gradients; transport ions, proteins, nucleic acids, nutrients, and metabolites; and provide transduction systems to sense the environment and to communicate with other cells. Membranes also provide shape and structure to cells and are important in cell motility. In addition, they fulfill a scaffolding function for proteins and organelles that interact with the extracellular environment. Written by specialists in the field, this book provides a comprehensive overview of the structural and molecular biology of cellular processes that occur at or near bacterial membranes. The book presents and discusses recent progress on the function and involvement of membranes in bacterial physiology, enabling a greater understanding of the molecular details of the cell envelope, its biogenesis, and its function. The topics covered include: cell wall growth * shape and division * the outer membrane of Gram-negative bacteria * outer membrane protein biosynthesis * bacterial lipoproteins * mycobacteria * lipid composition * ABC transporters * transport across the outer membrane * drug passage across membranes * bacterial membrane proteins * secretion systems * signal transduction * signalling mechanisms * bacterial membranes in adhesion and pathogenesis * membranes as a drug target. This cutting-edge text will provide a valuable resource for all those working in this field and is recommended for all microbiology libraries. - Description from Syndetics
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Ebsco eBook
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Bionanotechnology : Biological Self-assembly and Its Applications
by Rehm, Bernd

9781908230164Bernd H. A. Rehm (Editor)Bionanotechnology: Biological Self-Assembly and Its ApplicationsThe emerging science of bionanotechnology refers to the harnessing of the vast diversity of self-assembling building blocks and processes for the assembly of nano-scaled structures for the manufacture of highly functional nanomaterials. Bionanotechnology is an interdisciplinary field. It combines biological principles with physical and chemical procedures to generate nano-sized building blocks and materials with specific functions and new properties. It involves the development of biologically-based procedures, the use of biological components and systems, the design of biocompatible objects and systems, and the use of nanotechnology to support biotechnological processes. This book provides a survey of the most striking and successful approaches for the production of biogenic nanodevices, considering not only living organisms as manufacturer, but also in vitro processes that utilize the self-assembly of isolated biomolecules. It presents a topical overview of the vast field of bionanotechnology by describing various biological nanostructures, the implied design space, and the enormous potential for applications in medicine and technology. Two chapters describe the microbial production of tailor-made self-assembled nanostructures which can be processed into functional nanoparticles. Additional chapters comprehensively summarize recent developments in the use of protein-based assemblies for nanodevice and nanomaterials production. Topics include: polymer synthesis * self-assembly and display technology * self-assembly and application of cellulosomal components * protein-aided mineralization of inorganic nanostructures * amyloid fibrils as bionanomaterials * self-assembly and applications of bacteriophages and virus-like particles * plant oil bodies and oleosins-structure function and biotechnological applications * visual restoration using microbial rhodopsins * magnetosomes and liposome-nanoparticle assemblies. This is a recommended book for anyone interested in the fields of nanotechnology, biotechnology, metabolic engineering, molecular biology, genetic engineering, and protein design. - Description from Syndetics
Call Number:
Ebsco eBook
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The Double Helix
by James Watson

9780393950755James D. Watson; Gunther S. StentThe Double Helix: A Personal Account of the Discovery of the Structure of DNABackground materials include reproductions of the original scientific papers in which the double helical structure of DNA was first presented in 1953 and 1954.In Criticism, which begins with "A Review of the Reviews" by Gunther Stent, other scientists and scholars reveal their own experiences and views of Watson's story. There are reviews by Philip Morrison, F. X. S., Richard C. Lewontin, Mary Ellmann, Robert L. Sinsheimer, John Lear, Alex Comfort, Jacob Bronowski, Conrad H. Waddington, Robert K. Merton, Peter M. Medawar, and André Lwoff; as well as three letters to the editor of Science by Max F. Perutz, M. H. F. Wilkins, and James D. Watson. - Description from Syndetics

Frankenstein's cat : cuddling up to biotech's brave new beasts
by Emily Anthes

9780374158590Emily AnthesFrankenstein's Cat: Cuddling up to Biotech's Brave New Beasts Winner of 2014 AAAS/Subaru SB&F Prize for Best Young Adult Science Book Longlisted for the PEN/E.O. Wilson Literary Science Writing Award One of Nature 's Summer Book Picks One of Publishers Weekly 's Top Ten Spring 2013 Science Books For centuries, we've toyed with our creature companions, breeding dogs that herd and hunt, housecats that look like tigers, and teacup pigs that fit snugly in our handbags. But what happens when we take animal alteration a step further, engineering a cat that glows green under ultraviolet light or cloning the beloved family Labrador? Science has given us a whole new toolbox for tinkering with life. How are we using it? In Frankenstein ' s Cat , the journalist Emily Anthes takes us from petri dish to pet store as she explores how biotechnology is shaping the future of our furry and feathered friends. As she ventures from bucolic barnyards to a "frozen zoo" where scientists are storing DNA from the planet's most exotic creatures, she discovers how we can use cloning to protect endangered species, craft prosthetics to save injured animals, and employ genetic engineering to supply farms with disease-resistant livestock. Along the way, we meet some of the animals that are ushering in this astonishing age of enhancement, including sensor-wearing seals, cyborg beetles, a bionic bulldog, and the world's first cloned cat. Through her encounters with scientists, conservationists, ethicists, and entrepreneurs, Anthes reveals that while some of our interventions may be trivial (behold: the GloFish), others could improve the lives of many species-including our own. So what does biotechnology really mean for the world's wild things? And what do our brave new beasts tell us about ourselves? With keen insight and her trademark spunk, Anthes highlights both the peril and the promise of our scientific superpowers, taking us on an adventure into a world where our grandest science fiction fantasies are fast becoming reality. - Description from Syndetics

What is life? : investigating the nature of life in the age of synthetic biolog
by Ed Regis

9780374288518Ed RegisWhat Is Life?: Investigating the Nature of Life in the Age of Synthetic BiologyIn 1944, the Nobel Prize-winning physicist Erwin Schrodinger published a groundbreaking little book called What Is Life? In fewer than one hundred pages, he argued that life was not a mysterious or inexplicable phenomenon, as many people believed, but a scientific process like any other, ultimately explainable by the laws of physics and chemistry. Today, more than sixty years later, members of a new generation of scientists are attempting to create life from the ground up. Science has moved forward in leaps and bounds since Schrodinger's time, but our understanding of what does and does not constitute life has only grown more complex. An era that has already seen computer chip-implanted human brains, genetically engineered organisms, genetically modified foods, cloned mammals, and brain-dead humans kept alive by machines is one that demands fresh thinking about the concept of life. While a segment of our national debate remains stubbornly mired in moral quandaries over abortion, euthanasia, and other right to life issues, the science writer Ed Regis demonstrates how science can and does provide us with a detailed understanding of the nature of life. Written in a lively and accessible style, and synthesizing a wide range of contemporary research, What Is Life? is a brief and illuminating contribution to an age-old debate. - Description from Syndetics

Regenesis [electronic resource] : how synthetic biology will reinvent nature and ourselves
by George M. Church and Ed Regis.

9780465033294George M. Church; Edward RegisRegenesis: How Synthetic Biology Will Reinvent Nature and OurselvesEveryone has heard of genetic engineering: we eat engineered foods, we take drugs made in engineered bacteria and yeast, and someday soon may drive our cars on fuel produced by engineered microorganisms. "Regenesis" is the story of where these technologies came from, and where theyOCOre going, told by the man leading the revolution: Harvard genetics professor George Church. While traditional genetic engineering introduces changes to an organism a few genes at a time, genomic engineering introduces changes on a wholesale basis, allowing for unprecedented feats of synthetic biological engineering. (The technique, called MAGE, was invented by the author.) In "Regenesis," Church argues for the great potential of this technology, not only to make existing organisms more useful, but for inventing wholly new speciesOCobacterial, animal, and human. It promises to be a strange future, with biohackers building organisms in their garages, companies manufacturing toolkits of DNA parts for creating living machines, and much else. Researchers have already managed to get microbes to produce jet fuel, gasoline, and electricity. And even vaccines, drugs, and industrial chemicals (OC green chemistryOCO). They can reprogram bacteria to metabolize greenhouse gases and convert them into harmless, even beneficial substances. Still, incredible as they might seem, these exploits are minor advances compared to the catalog of wonders that full-blown genomic engineering will make possible, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms immune to disease. The rise of synthetic biology marks a fundamental transformation in the relationship between biology and nature. When humans can control the genetic makeup of organisms to the extent foreseen by synthetic biologists, nature will no longer be the exclusive arbiter of life, death, and evolution. "Regenesis" reveals what this not so far off future will look like. - Description from Syndetics

How we became posthuman : virtual bodies in cybernetics, literature, and informatics
by N. Katherine Hayles

9780226321462N. Katherine HaylesHow We Became Posthuman: Virtual Bodies in Cybernetics, Literature, and InformaticsIn this age of DNA computers and artificial intelligence, information is becoming disembodied even as the "bodies" that once carried it vanish into virtuality. While some marvel at these changes, envisioning consciousness downloaded into a computer or humans "beamed" Star Trek -style, others view them with horror, seeing monsters brooding in the machines. In How We Became Posthuman, N. Katherine Hayles separates hype from fact, investigating the fate of embodiment in an information age. Hayles relates three interwoven stories: how information lost its body, that is, how it came to be conceptualized as an entity separate from the material forms that carry it; the cultural and technological construction of the cyborg; and the dismantling of the liberal humanist "subject" in cybernetic discourse, along with the emergence of the "posthuman." Ranging widely across the history of technology, cultural studies, and literary criticism, Hayles shows what had to be erased, forgotten, and elided to conceive of information as a disembodied entity. Thus she moves from the post-World War II Macy Conferences on cybernetics to the 1952 novel Limbo by cybernetics aficionado Bernard Wolfe; from the concept of self-making to Philip K. Dick's literary explorations of hallucination and reality; and from artificial life to postmodern novels exploring the implications of seeing humans as cybernetic systems. Although becoming posthuman can be nightmarish, Hayles shows how it can also be liberating. From the birth of cybernetics to artificial life, How We Became Posthuman provides an indispensable account of how we arrived in our virtual age, and of where we might go from here. - Description from Syndetics

What is life?
by Lynn Margulis, Dorion Sagan

9780520220218Lynn Margulis; Dorion Sagan; Niles Eldredge (Foreword by)What Is Life?Half a century ago, before the discovery of DNA, the Austrian physicist and philosopher Erwin Schrödinger inspired a generation of scientists by rephrasing the fascinating philosophical question: What is life? Using their expansive understanding of recent science to wonderful effect, acclaimed authors Lynn Margulis and Dorion Sagan revisit this timeless question in a fast-moving, wide-ranging narrative that combines rigorous science with philosophy, history, and poetry. The authors move deftly across a dazzling array of topics--from the dynamics of the bacterial realm, to the connection between sex and death, to theories of spirit and matter. They delve into the origins of life, offering the startling suggestion that life--not just human life--is free to act and has played an unexpectedly large part in its own evolution. Transcending the various formal concepts of life, this captivating book offers a unique overview of life's history, essences, and future. Supplementing the text are stunning illustrations that range from the smallest known organism (Mycoplasma bacteria) to the largest (the biosphere itself). Creatures both strange and familiar enhance the pages of What Is Life? Their existence prompts readers to reconsider preconceptions not only about life but also about their own part in it. - Description from Syndetics

Genentech : the beginnings of biotech
by Sally Smith Hughes

9780226045511Sally Smith HughesGenentech: The Beginnings of BiotechIn the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise. Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech's improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech's science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech's founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits. Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it. - Description from Syndetics

The immortal life of Henrietta Lacks
by Rebecca Skloot

9781400052172Rebecca SklootThe Immortal Life of Henrietta LacksNow a major motion picture from HBO® starring Oprah Winfrey and Rose Byrne. Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells--taken without her knowledge--became one of the most important tools in medicine. The first "immortal" human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they'd weigh more than 50 million metric tons--as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vacci≠ uncovered secrets of cancer, viruses, and the atom bomb's effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Now Rebecca Skloot takes us on an extraordinary journey, from the "colored" ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta's small, dying hometown of Clover, Virginia--a land of wooden slave quarters, faith healings, and voodoo--to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells. Henrietta's family did not learn of her "immortality" until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family--past and present--is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family--especially Henrietta's daughter Deborah, who was devastated to learn about her mother's cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn't her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences. - Description from Syndetics

Stem cell research: new developments
by Tanaka, Hiroshi; Chang, Michael C. F

9781619420816Hiroshi Tanaka; Michael C. F. ChangStem Cell Research: New DevelopmentsAmong the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialized cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book brings together leading research from throughout the world in this frontier field. - Description from Syndetics

Never let me go
by Kazuo Ishiguro

9781400043392Kazuo IshiguroNever Let Me GoFrom the acclaimed author of The Remains of the Day and When We Were Orphans, a moving new novel that subtly reimagines our world and time in a haunting story of friendship and love. As a child, Kathy-now thirty-one years old-lived at Hailsham, a private school in the scenic English countryside where the children were sheltered from the outside world, brought up to believe that they were special and that their well-being was crucial not only for themselves but for the society they would eventually enter. Kathy had long ago put this idyllic past behind her, but when two of her Hailsham friends come back into her life, she stops resisting the pull of memory. And so, as her friendship with Ruth is rekindled, and as the feelings that long ago fueled her adolescent crush on Tommy begin to deepen into love, Kathy recalls their years at Hailsham. She describes happy scenes of boys and girls growing up together, unperturbed-even comforted-by their isolation. But she describes other scenes as well: of discord and misunderstanding that hint at a dark secret behind Hailsham's nurturing facade. With the dawning clarity of hindsight, the three friends are compelled to face the truth about their childhood-and about their lives now. A tale of deceptive simplicity, Never Let Me Go slowly reveals an extraordinary emotional depth and resonance-and takes its place among Kazuo Ishiguro's finest work. - Description from Syndetics

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